SpyMask enables combinatorial assembly of bispecific binders
SpyMask enables combinatorial assembly of bispecific binders
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Bispecific antibodies are a successful and expanding therapeutic class. Standard approaches to generate bispecifics are complicated by the need for disulfide reduction/oxidation or specialized formats. Here we present SpyMask, a modular approach to bispecifics using SpyTag/SpyCatcher spontaneous amidation. Two SpyTag-fused antigen-binding modules c...
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Full title
SpyMask enables combinatorial assembly of bispecific binders
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TN_cdi_doaj_primary_oai_doaj_org_article_c19781fa915843b1a0ec4d336331467c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c19781fa915843b1a0ec4d336331467c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-46599-9
