Discovery of novel JAK1 inhibitors through combining machine learning, structure-based pharmacophore...
Discovery of novel JAK1 inhibitors through combining machine learning, structure-based pharmacophore modeling and bio-evaluation
About this item
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Author / Creator
Wang, Zixiao , Sun, Lili , Xu, Yu , Liang, Peida , Xu, Kaiyan and Huang, Jing
Publisher
London: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
London: BioMed Central Ltd
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Scope and Contents
Contents
Background Janus kinase 1 (JAK1) plays a critical role in most cytokine-mediated inflammatory, autoimmune responses and various cancers via the JAK/STAT signaling pathway. Inhibition of JAK1 is therefore an attractive therapeutic strategy for several diseases. Recently, high-performance machine learning techniques have been increasingly applied in...
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Full title
Discovery of novel JAK1 inhibitors through combining machine learning, structure-based pharmacophore modeling and bio-evaluation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c1b7875ad0b44664adafc93b54d25693
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c1b7875ad0b44664adafc93b54d25693
Other Identifiers
ISSN
1479-5876
E-ISSN
1479-5876
DOI
10.1186/s12967-023-04443-6
