Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptors. Receptors with the intracellular domain of IGF1...
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Full title
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
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TN_cdi_doaj_primary_oai_doaj_org_article_c27316e5cd6942f09a89e65936cda8b3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c27316e5cd6942f09a89e65936cda8b3
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14892
