Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotro...
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
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Author / Creator
Medina-Gomez, Carolina , Kemp, John P. , Dimou, Niki L. , Kreiner, Eskil , Chesi, Alessandra , Zemel, Babette S. , Bønnelykke, Klaus , Boer, Cindy G. , Ahluwalia, Tarunveer S. , Bisgaard, Hans , Evangelou, Evangelos , Heppe, Denise H. M. , Bonewald, Lynda F. , Gorski, Jeffrey P. , Ghanbari, Mohsen , Demissie, Serkalem , Duque, Gustavo , Maurano, Matthew T. , Kiel, Douglas P. , Hsu, Yi-Hsiang , C.J. van der Eerden, Bram , Ackert-Bicknell, Cheryl , Reppe, Sjur , Gautvik, Kaare M. , Raastad, Truls , Karasik, David , van de Peppel, Jeroen , Jaddoe, Vincent W. V. , Uitterlinden, André G. , Tobias, Jonathan H. , Grant, Struan F.A. , Bagos, Pantelis G. , Evans, David M. and Rivadeneira, Fernando
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
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Contents
Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS meta-analysis of total-body lean mass (TB-LM) and total-body less head bone mineral density (TBLH-BMD) regions in 10,414 childre...
Alternative Titles
Full title
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
Authors, Artists and Contributors
Author / Creator
Kemp, John P.
Dimou, Niki L.
Kreiner, Eskil
Chesi, Alessandra
Zemel, Babette S.
Bønnelykke, Klaus
Boer, Cindy G.
Ahluwalia, Tarunveer S.
Bisgaard, Hans
Evangelou, Evangelos
Heppe, Denise H. M.
Bonewald, Lynda F.
Gorski, Jeffrey P.
Ghanbari, Mohsen
Demissie, Serkalem
Duque, Gustavo
Maurano, Matthew T.
Kiel, Douglas P.
Hsu, Yi-Hsiang
C.J. van der Eerden, Bram
Ackert-Bicknell, Cheryl
Reppe, Sjur
Gautvik, Kaare M.
Raastad, Truls
Karasik, David
van de Peppel, Jeroen
Jaddoe, Vincent W. V.
Uitterlinden, André G.
Tobias, Jonathan H.
Grant, Struan F.A.
Bagos, Pantelis G.
Evans, David M.
Rivadeneira, Fernando
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c29862cdbe2e426d82346b87b13a5d6e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c29862cdbe2e426d82346b87b13a5d6e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00108-3
