Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo...
Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells
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Author / Creator
Megiorni, Francesca , Gravina, Giovanni Luca , Camero, Simona , Ceccarelli, Simona , Del Fattore, Andrea , Desiderio, Vincenzo , Papaccio, Federica , McDowell, Heather P , Shukla, Rajeev , Pizzuti, Antonio , Beirinckx, Filip , Pujuguet, Philippe , Saniere, Laurent , der Aar, Ellen Van , Maggio, Roberto , De Felice, Francesca , Marchese, Cinzia , Dominici, Carlo , Tombolini, Vincenzo , Festuccia, Claudio and Marampon, Francesco
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
EPH (erythropoietin-producing hepatocellular) receptors are clinically relevant targets in several malignancies. This report describes the effects of GLPG1790, a new potent pan-EPH inhibitor, in human embryonal rhabdomyosarcoma (ERMS) cell lines.
EPH-A2 and Ephrin-A1 mRNA expression was quantified by real-time PCR in 14 ERMS tumour samples and i...
Alternative Titles
Full title
Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells
Authors, Artists and Contributors
Author / Creator
Gravina, Giovanni Luca
Camero, Simona
Ceccarelli, Simona
Del Fattore, Andrea
Desiderio, Vincenzo
Papaccio, Federica
McDowell, Heather P
Shukla, Rajeev
Pizzuti, Antonio
Beirinckx, Filip
Pujuguet, Philippe
Saniere, Laurent
der Aar, Ellen Van
Maggio, Roberto
De Felice, Francesca
Marchese, Cinzia
Dominici, Carlo
Tombolini, Vincenzo
Festuccia, Claudio
Marampon, Francesco
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c2ec0ef788624ddf8f31c6257cf4ffc9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c2ec0ef788624ddf8f31c6257cf4ffc9
Other Identifiers
ISSN
1756-8722
E-ISSN
1756-8722
DOI
10.1186/s13045-017-0530-z
