The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-eff...
The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo
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England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Effective mucosal adjuvants enhance the magnitude and quality of the vaccine response. Cyclic di-GMP (CDG) is a promising mucosal vaccine adjuvant. However, its in vivo mechanisms are unclear. Here, we showed, in mice, that CDG elicits stronger Ab and TH responses than the mammalian 2′3′-cyclic GMP-AMP (cGAMP), and generated better protection again...
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Full title
The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo
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TN_cdi_doaj_primary_oai_doaj_org_article_c2ec54ef24b7447fb9d686e234b10655
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c2ec54ef24b7447fb9d686e234b10655
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.06670
