The Multifaceted Histidine-Based Carriers for Nucleic Acid Delivery: Advances and Challenges
The Multifaceted Histidine-Based Carriers for Nucleic Acid Delivery: Advances and Challenges
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Histidines incorporated into carriers of nucleic acids may enhance the extracellular stability of the nanoparticle, yet aid in the intracellular disruption of the nanoparticle, enabling the release of the nucleic acid. Moreover, protonation of histidines in the endosomes may result in endosomal swelling with subsequent lysis. These properties of hi...
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Full title
The Multifaceted Histidine-Based Carriers for Nucleic Acid Delivery: Advances and Challenges
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TN_cdi_doaj_primary_oai_doaj_org_article_c3aa6c61152c4b939af9228f27a43842
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c3aa6c61152c4b939af9228f27a43842
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ISSN
1999-4923
E-ISSN
1999-4923
DOI
10.3390/pharmaceutics12080774
