Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury
Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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RIP1 kinase-mediated inflammatory and cell death pathways have been implicated in the pathology of acute and chronic disorders of the nervous system. Here, we describe a novel animal model of RIP1 kinase deficiency, generated by knock-in of the kinase-inactivating RIP1(D138N) mutation in rats. Homozygous RIP1 kinase-dead (KD) rats had normal develo...
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Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury
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TN_cdi_doaj_primary_oai_doaj_org_article_c403fe72c3fe41429f8c35b23860a00f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c403fe72c3fe41429f8c35b23860a00f
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-021-03651-6
