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The antipsychotic agent sulpiride microinjected into the ventral pallidum restores positive symptom-...

The antipsychotic agent sulpiride microinjected into the ventral pallidum restores positive symptom-...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c40ee9a7edb24e60b5a967997dff4717

The antipsychotic agent sulpiride microinjected into the ventral pallidum restores positive symptom-like habituation disturbance in MAM-E17 schizophrenia model rats

About this item

Full title

The antipsychotic agent sulpiride microinjected into the ventral pallidum restores positive symptom-like habituation disturbance in MAM-E17 schizophrenia model rats

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2024-05, Vol.14 (1), p.12305-12, Article 12305

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Dysfunction of subcortical D2-like dopamine receptors (D
2
Rs) can lead to positive symptoms of schizophrenia, and their analog, the increased locomotor activity in schizophrenia model MAM-E17 rats. The ventral pallidum (VP) is a limbic structure containing D
2
Rs. The D
2
R antagonist sulpiride is a widespread antipsychotic drug,...

Alternative Titles

Full title

The antipsychotic agent sulpiride microinjected into the ventral pallidum restores positive symptom-like habituation disturbance in MAM-E17 schizophrenia model rats

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_c40ee9a7edb24e60b5a967997dff4717

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c40ee9a7edb24e60b5a967997dff4717

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-024-63059-y

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