Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells...
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
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Author / Creator
Cano-Gamez, Eddie , Soskic, Blagoje , Roumeliotis, Theodoros I. , So, Ernest , Smyth, Deborah J. , Baldrighi, Marta , Willé, David , Nakic, Nikolina , Esparza-Gordillo, Jorge , Larminie, Christopher G. C. , Bronson, Paola G. , Tough, David F. , Rowan, Wendy C. , Choudhary, Jyoti S. and Trynka, Gosia
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Naïve CD4
+
T cells coordinate the immune response by acquiring an effector phenotype in response to cytokines. However, the cytokine responses in memory T cells remain largely understudied. Here we use quantitative proteomics, bulk RNA-seq, and single-cell RNA-seq of over 40,000 human naïve and memory CD4
+
T cells to show that respons...
Alternative Titles
Full title
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c41d5eba344a432094f61c1d23ca9074
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c41d5eba344a432094f61c1d23ca9074
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15543-y
