TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase
TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase
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Author / Creator
Liu, Gang , Haw, Tatt Jhong , Starkey, Malcolm R. , Philp, Ashleigh M. , Pavlidis, Stelios , Nalkurthi, Christina , Nair, Prema M. , Gomez, Henry M. , Hanish, Irwan , Hsu, Alan CY , Hortle, Elinor , Pickles, Sophie , Rojas-Quintero, Joselyn , Estepar, Raul San Jose , Marshall, Jacqueline E. , Kim, Richard Y. , Collison, Adam M. , Mattes, Joerg , Idrees, Sobia , Faiz, Alen , Hansbro, Nicole G. , Fukui, Ryutaro , Murakami, Yusuke , Cheng, Hong Sheng , Tan, Nguan Soon , Chotirmall, Sanjay H. , Horvat, Jay C. , Foster, Paul S. , Oliver, Brian GG , Polverino, Francesca , Ieni, Antonio , Monaco, Francesco , Caramori, Gaetano , Sohal, Sukhwinder S. , Bracke, Ken R. , Wark, Peter A. , Adcock, Ian M. , Miyake, Kensuke , Sin, Don D. and Hansbro, Philip M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that the severity of CS-induced emphysema and COPD is reduced in TLR7-deficient mice, while inhalation of imiquimod,...
Alternative Titles
Full title
TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase
Authors, Artists and Contributors
Author / Creator
Haw, Tatt Jhong
Starkey, Malcolm R.
Philp, Ashleigh M.
Pavlidis, Stelios
Nalkurthi, Christina
Nair, Prema M.
Gomez, Henry M.
Hanish, Irwan
Hsu, Alan CY
Hortle, Elinor
Pickles, Sophie
Rojas-Quintero, Joselyn
Estepar, Raul San Jose
Marshall, Jacqueline E.
Kim, Richard Y.
Collison, Adam M.
Mattes, Joerg
Idrees, Sobia
Faiz, Alen
Hansbro, Nicole G.
Fukui, Ryutaro
Murakami, Yusuke
Cheng, Hong Sheng
Tan, Nguan Soon
Chotirmall, Sanjay H.
Horvat, Jay C.
Foster, Paul S.
Oliver, Brian GG
Polverino, Francesca
Ieni, Antonio
Monaco, Francesco
Caramori, Gaetano
Sohal, Sukhwinder S.
Bracke, Ken R.
Wark, Peter A.
Adcock, Ian M.
Miyake, Kensuke
Sin, Don D.
Hansbro, Philip M.
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c49c73a4f4614f95ae1cab28b0686048
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c49c73a4f4614f95ae1cab28b0686048
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42913-z
