Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila
Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
The anticancer drug camptothecin (CPT), first isolated from Camptotheca acuminata, was subsequently discovered in unrelated plants, including Ophiorrhiza pumila. Unlike known monoterpene indole alkaloids, CPT in C. acuminata is biosynthesized via the key intermediate strictosidinic acid, but how O. pumila synthesizes CPT has not been determined.
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Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila
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TN_cdi_doaj_primary_oai_doaj_org_article_c4a98c4f4e9b4852a145d7d4ad86f8db
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c4a98c4f4e9b4852a145d7d4ad86f8db
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ISSN
1741-7007
E-ISSN
1741-7007
DOI
10.1186/s12915-021-01051-y
