Searching for molecular hypoxia sensors among oxygen-dependent enzymes
Searching for molecular hypoxia sensors among oxygen-dependent enzymes
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Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen-dependent enzyme PHD: hypoxia inhibits its ability to hydroxylate the transcription factor HIF, causing HIF to accumulate and trigger the classic HIF-dependent hypoxia...
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Full title
Searching for molecular hypoxia sensors among oxygen-dependent enzymes
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TN_cdi_doaj_primary_oai_doaj_org_article_c4c9979e2d5f41528e4321ca0ea7b27f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c4c9979e2d5f41528e4321ca0ea7b27f
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.87705
