Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
About this item
Full title
Author / Creator
Mangolini, Maurizio , Götte, Frederik , Moore, Andrew , Ammon, Tim , Oelsner, Madlen , Lutzny-Geier, Gloria , Klein-Hitpass, Ludger , Williamson, James C. , Lehner, Paul J. , Dürig, Jan , Möllmann, Michael , Rásó-Barnett, Lívia , Hughes, Katherine , Santoro, Antonella , Méndez-Ferrer, Simón , Oostendorp, Robert A. J. , Zimber-Strobl, Ursula , Peschel, Christian , Hodson, Daniel J. , Schmidt-Supprian, Marc and Ringshausen, Ingo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The Wnt signalling pathway, one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL), is activated in only a subset of patients through somatic mutations. Here we describe alternative, microenvironment-dependent mechanisms of Wnt activation in malignant B cells. We show that tumour cells specifically induce Notch2 activity in me...
Alternative Titles
Full title
Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
Authors, Artists and Contributors
Author / Creator
Götte, Frederik
Moore, Andrew
Ammon, Tim
Oelsner, Madlen
Lutzny-Geier, Gloria
Klein-Hitpass, Ludger
Williamson, James C.
Lehner, Paul J.
Dürig, Jan
Möllmann, Michael
Rásó-Barnett, Lívia
Hughes, Katherine
Santoro, Antonella
Méndez-Ferrer, Simón
Oostendorp, Robert A. J.
Zimber-Strobl, Ursula
Peschel, Christian
Hodson, Daniel J.
Schmidt-Supprian, Marc
Ringshausen, Ingo
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c4f9c099f3104cabbf026773512a17d1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c4f9c099f3104cabbf026773512a17d1
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06069-5
