The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse...
The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology
About this item
Full title
Author / Creator
Martinez Hernandez, Ana , Urbanke, Hendrik , Gillman, Alan L , Lee, Joon , Ryazanov, Sergey , Agbemenyah, Hope Y , Benito, Eva , Jain, Gaurav , Kaurani, Lalit , Grigorian, Gayane , Leonov, Andrei , Rezaei‐Ghaleh, Nasrollah , Wilken, Petra , Arce, Fernando Teran , Wagner, Jens , Fuhrmann, Martin , Caruana, Mario , Camilleri, Angelique , Vassallo, Neville , Zweckstetter, Markus , Benz, Roland , Giese, Armin , Schneider, Anja , Korte, Martin , Lal, Ratnesh , Griesinger, Christian , Eichele, Gregor and Fischer, Andre
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Alzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally befor...
Alternative Titles
Full title
The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology
Authors, Artists and Contributors
Author / Creator
Urbanke, Hendrik
Gillman, Alan L
Lee, Joon
Ryazanov, Sergey
Agbemenyah, Hope Y
Benito, Eva
Jain, Gaurav
Kaurani, Lalit
Grigorian, Gayane
Leonov, Andrei
Rezaei‐Ghaleh, Nasrollah
Wilken, Petra
Arce, Fernando Teran
Wagner, Jens
Fuhrmann, Martin
Caruana, Mario
Camilleri, Angelique
Vassallo, Neville
Zweckstetter, Markus
Benz, Roland
Giese, Armin
Schneider, Anja
Korte, Martin
Lal, Ratnesh
Griesinger, Christian
Eichele, Gregor
Fischer, Andre
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c508142ad7ed44dda436f67105c1fa85
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c508142ad7ed44dda436f67105c1fa85
Other Identifiers
ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201707825
