Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I...
Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Angelman syndrome (AS) is a severe neurodevelopmental disorder lacking effective therapies. AS is caused by mutations in ubiquitin protein ligase E3A (
), which is genomically imprinted such that only the maternally inherited copy is expressed in neurons. We previously demonstrated that topoisomerase I (Top1) inhibitors could successfully reacti...
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Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome
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TN_cdi_doaj_primary_oai_doaj_org_article_c541caeabe464ea5a476b5d7d069d82a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c541caeabe464ea5a476b5d7d069d82a
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ISSN
2040-2392
E-ISSN
2040-2392
DOI
10.1186/s13229-018-0228-2
