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Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast can...

Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast can...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c56b41a143f64bd2b1690c2b26be55c4

Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast cancer

About this item

Full title

Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast cancer

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2023-04, Vol.14 (1), p.2109-2109, Article 2109

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Chemotherapy prior to immune checkpoint blockade (ICB) treatment appears to improve ICB efficacy but resistance to ICB remains a clinical challenge and is attributed to highly plastic myeloid cells associating with the tumor immune microenvironment (TIME). Here we show by CITE-seq single-cell transcriptomic and trajectory analyses that neoadjuvant...

Alternative Titles

Full title

Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_c56b41a143f64bd2b1690c2b26be55c4

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c56b41a143f64bd2b1690c2b26be55c4

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-023-37727-y

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