Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibro...
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
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Author / Creator
Strunz, Maximilian , Simon, Lukas M. , Ansari, Meshal , Kathiriya, Jaymin J. , Angelidis, Ilias , Mayr, Christoph H. , Tsidiridis, George , Lange, Marius , Mattner, Laura F. , Yee, Min , Ogar, Paulina , Sengupta, Arunima , Kukhtevich, Igor , Schneider, Robert , Zhao, Zhongming , Voss, Carola , Stoeger, Tobias , Neumann, Jens H. L. , Hilgendorff, Anne , Behr, Jürgen , O’Reilly, Michael , Lehmann, Mareike , Burgstaller, Gerald , Königshoff, Melanie , Chapman, Harold A. , Theis, Fabian J. and Schiller, Herbert B.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The cell type specific sequences of transcriptional programs during lung regeneration have remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, we resolved transcriptional dynamics for 28 cell types. Trajectory modeling together with lineage tracing revealed that airway and alveolar stem cells converge on a un...
Alternative Titles
Full title
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
Authors, Artists and Contributors
Author / Creator
Simon, Lukas M.
Ansari, Meshal
Kathiriya, Jaymin J.
Angelidis, Ilias
Mayr, Christoph H.
Tsidiridis, George
Lange, Marius
Mattner, Laura F.
Yee, Min
Ogar, Paulina
Sengupta, Arunima
Kukhtevich, Igor
Schneider, Robert
Zhao, Zhongming
Voss, Carola
Stoeger, Tobias
Neumann, Jens H. L.
Hilgendorff, Anne
Behr, Jürgen
O’Reilly, Michael
Lehmann, Mareike
Burgstaller, Gerald
Königshoff, Melanie
Chapman, Harold A.
Theis, Fabian J.
Schiller, Herbert B.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c56bf52cb142499c98ef8cc384553dbe
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c56bf52cb142499c98ef8cc384553dbe
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17358-3
