Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity...
Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts
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Author / Creator
Cutolo, Maurizio , Ruaro, Barbara , Montagna, Paola , Brizzolara, Renata , Stratta, Emanuela , Trombetta, Amelia Chiara , Scabini, Stefano , Tavilla, Pier Paolo , Parodi, Aurora , Corallo, Claudio , Giordano, Nicola , Paolino, Sabrina , Pizzorni, Carmen , Sulli, Alberto , Smith, Vanessa and Soldano, Stefano
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Myofibroblasts contribute to fibrosis through the overproduction of extracellular matrix (ECM) proteins, primarily type I collagen (COL-1) and fibronectin (FN), a process which is mediated in systemic sclerosis (SSc) by the activation of fibrogenic intracellular signaling transduction molecules, including extracellular signal-regulated kinases 1 an...
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Full title
Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c64cf8838a404481be96cc3fe1140e22
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c64cf8838a404481be96cc3fe1140e22
Other Identifiers
ISSN
1478-6362,1478-6354
E-ISSN
1478-6362
DOI
10.1186/s13075-018-1577-0
