Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
TRPV6 is a calcium-selective ion channel implicated in epithelial Ca
2+
uptake. TRPV6 inhibitors are needed for the treatment of a broad range of diseases associated with disturbed calcium homeostasis, including cancers. Here we combine cryo-EM, calcium imaging, and mutagenesis to explore molecular bases of human TRPV6 inhibition by the antif...
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Full title
Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
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TN_cdi_doaj_primary_oai_doaj_org_article_c655b2e004b0428cb1826694f8cb395f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c655b2e004b0428cb1826694f8cb395f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26608-x
