Tilorone mitigates the propagation of α-synucleinopathy in a midbrain-like organoid model
Tilorone mitigates the propagation of α-synucleinopathy in a midbrain-like organoid model
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Author / Creator
Zhang, Qi , Liu, Meng , Xu, Yue , Lee, Juhyung , Jones, Brothely , Li, Bing , Huang, Wenwei , Ye, Yihong and Zheng, Wei
Publisher
England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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Contents
Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of dopaminergic neurons and the accumulation of Lewy-body protein aggregates containing misfolded α-synuclein (α-syn) in a phosphorylated form. The lack of effective models for drug screens has hindered drug development studies for PD. However, the recent developmen...
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Full title
Tilorone mitigates the propagation of α-synucleinopathy in a midbrain-like organoid model
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c67167373fa8411581c509cf4d60295b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c67167373fa8411581c509cf4d60295b
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ISSN
1479-5876
E-ISSN
1479-5876
DOI
10.1186/s12967-024-05551-7
