Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer
Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer
About this item
Full title
Author / Creator
Ge, Jennifer Y. , Shu, Shaokun , Kwon, Mijung , Jovanović, Bojana , Murphy, Katherine , Gulvady, Anushree , Fassl, Anne , Trinh, Anne , Kuang, Yanan , Heavey, Grace A. , Luoma, Adrienne , Paweletz, Cloud , Thorner, Aaron R. , Wucherpfennig, Kai W. , Qi, Jun , Brown, Myles , Sicinski, Piotr , McDonald, Thomas O. , Pellman, David , Michor, Franziska and Polyak, Kornelia
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
BET inhibitors are promising therapeutic agents for the treatment of triple-negative breast cancer (TNBC), but the rapid emergence of resistance necessitates investigation of combination therapies and their effects on tumor evolution. Here, we show that palbociclib, a CDK4/6 inhibitor, and paclitaxel, a microtubule inhibitor, synergize with the BET...
Alternative Titles
Full title
Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer
Authors, Artists and Contributors
Author / Creator
Shu, Shaokun
Kwon, Mijung
Jovanović, Bojana
Murphy, Katherine
Gulvady, Anushree
Fassl, Anne
Trinh, Anne
Kuang, Yanan
Heavey, Grace A.
Luoma, Adrienne
Paweletz, Cloud
Thorner, Aaron R.
Wucherpfennig, Kai W.
Qi, Jun
Brown, Myles
Sicinski, Piotr
McDonald, Thomas O.
Pellman, David
Michor, Franziska
Polyak, Kornelia
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c6750e9707894301940edb49bbf81051
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c6750e9707894301940edb49bbf81051
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16170-3
