Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic...
Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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M1 macrophages enter a glycolytic state when endogenous nitric oxide (NO) reprograms mitochondrial metabolism by limiting aconitase 2 and pyruvate dehydrogenase (PDH) activity. Here, we provide evidence that NO targets the PDH complex by using lipoate to generate nitroxyl (HNO). PDH E2-associated lipoate is modified in NO-rich macrophages while the...
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Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming
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TN_cdi_doaj_primary_oai_doaj_org_article_c6b5815c95e344bdaaa97f1c13a3f7f7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c6b5815c95e344bdaaa97f1c13a3f7f7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-40738-4
