Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophe...
Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD
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Author / Creator
Lee, Seong Mi , Choi, Yura , Kim, Dayeon , Jeong, Ha Jin , Do, Young Ho , Jung, Sohee , Lee, Bomee , Choi, Hyung Jun , Kim, Suhyeon , Oh, Jung-Min , Jeon, Songhee , Han, Jinju and Kim, Yeni
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Autism spectrum disorder (ASD) is linked to ion channel dysfunction, including chloride voltage-gated channel-4 (
CLCN4
). We generated
Clcn4
knockout (KO) mice by deleting exon 5 of chromosome 7 in the C57BL/6 mice.
Clcn4
KO exhibited reduced social interaction and increased repetitive behaviors assessed using three-chamber and m...
Alternative Titles
Full title
Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD
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TN_cdi_doaj_primary_oai_doaj_org_article_c6b9034b90a14991b126ec667d7e25d6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c6b9034b90a14991b126ec667d7e25d6
Other Identifiers
ISSN
2158-3188
E-ISSN
2158-3188
DOI
10.1038/s41398-024-03201-6
