TMAO Promotes NLRP3 Inflammasome Activation of Microglia Aggravating Neurological Injury in Ischemic...
TMAO Promotes NLRP3 Inflammasome Activation of Microglia Aggravating Neurological Injury in Ischemic Stroke Through FTO/IGF2BP2
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Author / Creator
Ge, Pengxin , Duan, Huijie , Tao, Chunrong , Niu, Sensen , Hu, Yiran , Duan, Rui , Shen, Aizong , Sun, Yancai and Sun, Wen
Publisher
Dove Medical Press Limited
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Language
English
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Publisher
Dove Medical Press Limited
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Contents
Objective: Stroke is a kind of cerebrovascular disease with high mortality. TMAO has been shown to aggravate stroke outcomes, but its mechanism remains unclear. Materials and Methods: Mice were fed with 0.12% TMAO for 16 weeks. Then, mice were made into MCAO/R models. Neurological score, infarct volume, neuronal damage and markers associated with i...
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Full title
TMAO Promotes NLRP3 Inflammasome Activation of Microglia Aggravating Neurological Injury in Ischemic Stroke Through FTO/IGF2BP2
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TN_cdi_doaj_primary_oai_doaj_org_article_c6cfe28e71534fbab08760e03a331f1d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c6cfe28e71534fbab08760e03a331f1d
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ISSN
1178-7031
E-ISSN
1178-7031
DOI
10.2147/JIR.S399480
