Ready access to 7,8-dihydroindolo[2,3- d ][1]benzazepine-6(5 H )-one scaffold and analogues via earl...
Ready access to 7,8-dihydroindolo[2,3- d ][1]benzazepine-6(5 H )-one scaffold and analogues via early-stage Fischer ring-closure reaction
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Publisher
Germany: Beilstein-Institut zur Föerderung der Chemischen Wissenschaften
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Language
English
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Publisher
Germany: Beilstein-Institut zur Föerderung der Chemischen Wissenschaften
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Contents
Paullone isomers are known as inhibitors of tubulin polymerase and cyclin dependent kinases (Cdks), which are potential targets for cancer chemotherapy. Herein we report an efficient and clean pathway to the fourth isomer, which remained elusive so far, namely 7,8-dihydroindolo[2,3-
][1]benzazepin-6(5
)-one. Moreover, we demonstrate the gener...
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Ready access to 7,8-dihydroindolo[2,3- d ][1]benzazepine-6(5 H )-one scaffold and analogues via early-stage Fischer ring-closure reaction
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TN_cdi_doaj_primary_oai_doaj_org_article_c6e0b77b94054f58ad6b18a866173942
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c6e0b77b94054f58ad6b18a866173942
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ISSN
1860-5397,2195-951X
E-ISSN
1860-5397
DOI
10.3762/bjoc.18.15
