Click estradiol dimers with novel aromatic bridging units: synthesis and anticancer evaluation
Click estradiol dimers with novel aromatic bridging units: synthesis and anticancer evaluation
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England: Taylor & Francis Ltd
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Language
English
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England: Taylor & Francis Ltd
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Estradiol dimers (EDs) possess significant anticancer activity by targeting tubulin dynamics. In this study, we synthesised 12 EDs variants via copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction, focusing on structural modifications within the aromatic bridge connecting two estradiol moieties.
testing of these EDs revealed a marked imp...
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Click estradiol dimers with novel aromatic bridging units: synthesis and anticancer evaluation
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TN_cdi_doaj_primary_oai_doaj_org_article_c6ffcd1be2c54765a90525facd8c6a33
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c6ffcd1be2c54765a90525facd8c6a33
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ISSN
1475-6366,1475-6374
E-ISSN
1475-6374
DOI
10.1080/14756366.2024.2367139
