Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social be...
Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway
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Author / Creator
Birth Defects Research Laboratory , Guo, Yu , Shen, Minjie , Dong, Qiping , Méndez-Albelo, Natasha M. , Huang, Sabrina X. , Sirois, Carissa L. , Le, Jonathan , Li, Meng , Jarzembowski, Ezra D. , Schoeller, Keegan A. , Stockton, Michael E. , Horner, Vanessa L. , Sousa, André M. M. , Gao, Yu , Levine, Jon E. , Wang, Daifeng , Chang, Qiang and Zhao, Xinyu
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Fragile X messenger ribonucleoprotein 1 protein (FMRP) binds many mRNA targets in the brain. The contribution of these targets to fragile X syndrome (FXS) and related autism spectrum disorder (ASD) remains unclear. Here, we show that FMRP deficiency leads to elevated microtubule-associated protein 1B (MAP1B) in developing human and non-human primat...
Alternative Titles
Full title
Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway
Authors, Artists and Contributors
Author / Creator
Guo, Yu
Shen, Minjie
Dong, Qiping
Méndez-Albelo, Natasha M.
Huang, Sabrina X.
Sirois, Carissa L.
Le, Jonathan
Li, Meng
Jarzembowski, Ezra D.
Schoeller, Keegan A.
Stockton, Michael E.
Horner, Vanessa L.
Sousa, André M. M.
Gao, Yu
Levine, Jon E.
Wang, Daifeng
Chang, Qiang
Zhao, Xinyu
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c712033063bc4873a8e01bd8ebf89faa
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c712033063bc4873a8e01bd8ebf89faa
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-39337-0
