Genetically stable CRISPR-based kill switches for engineered microbes
Genetically stable CRISPR-based kill switches for engineered microbes
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Microbial biocontainment is an essential goal for engineering safe, next-generation living therapeutics. However, the genetic stability of biocontainment circuits, including kill switches, is a challenge that must be addressed. Kill switches are among the most difficult circuits to maintain due to the strong selection pressure they impart, leading...
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Genetically stable CRISPR-based kill switches for engineered microbes
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TN_cdi_doaj_primary_oai_doaj_org_article_c781c73e86f744feb43e92b1032cd16e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c781c73e86f744feb43e92b1032cd16e
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-28163-5
