Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling
Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling
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Author / Creator
Yu, Jinjin , Li, Yingke , Li, Yiming , Liu, Xiaotian , Huo, Qingyang , Wu, Nan , Zhang, Yangxia , Zeng, Taoling , Zhang, Yong , Li, Henry You , Lian, Jie , Zhou, Jihong , Moses, Emmanuel Jairaj , Geng, Jian , Lin, Juntang , Li, Wei and Zhu, Xinxing
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The transcriptional repressor FOXN3 plays a key role in regulating pulmonary inflammatory responses, which are crucial in the development of pulmonary fibrosis. However, its specific regulatory function in lung fibrosis remains unclear. Here, we show that FOXN3 suppresses pulmonary fibrosis by inhibiting Smad transcriptional activity. FOXN3 targets...
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Full title
Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling
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TN_cdi_doaj_primary_oai_doaj_org_article_c79fa6fcbd4542f78c38d40e98d4fb41
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c79fa6fcbd4542f78c38d40e98d4fb41
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-56922-7
