Cancer proteome and metabolite changes linked to SHMT2
Cancer proteome and metabolite changes linked to SHMT2
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Author / Creator
Jiefei Tong , Jonathan R Krieger , Paul Taylor , Rick Bagshaw , Jae Kang , Swathi Jeedigunta , Leanne E Wybenga-Groot , Wen Zhang , Heba Badr , Shideh Mirhadi , Nhu-An Pham , Étienne Coyaud , Man Yu , Ming Li , Michael Cabanero , Brian Raught , Jason T Maynes , Cynthia Hawkins , Ming Sound Tsao and Michael F Moran
Publisher
Public Library of Science (PLoS)
Journal title
Language
English
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Publisher
Public Library of Science (PLoS)
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Scope and Contents
Contents
Serine hydroxymethyltransferase 2 (SHMT2) converts serine plus tetrahydrofolate (THF) into glycine plus methylene-THF and is upregulated at the protein level in lung and other cancers. In order to better understand the role of SHMT2 in cancer a model system of HeLa cells engineered for inducible over-expression or knock-down of SHMT2 was characteri...
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Full title
Cancer proteome and metabolite changes linked to SHMT2
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TN_cdi_doaj_primary_oai_doaj_org_article_c7f34d407c984a35b79c0dc38739259f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c7f34d407c984a35b79c0dc38739259f
Other Identifiers
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0237981
