Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo
Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo
About this item
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Author / Creator
Bertheloot, Damien , Wanderley, Carlos WS , Schneider, Ayda H , Schiffelers, Lisa DJ , Wuerth, Jennifer D , Tödtmann, Jan MP , Maasewerd, Salie , Hawwari, Ibrahim , Duthie, Fraser , Rohland, Cornelia , Ribeiro, Lucas S , Jenster, Lea‐Marie , Rosero, Nathalia , Tesfamariam, Yonas M , Cunha, Fernando Q , Schmidt, Florian I and Franklin, Bernardo S
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines. Caspase‐1 also drives pyroptosis, a lytic cell death characterized by leakage of intracellular content to t...
Alternative Titles
Full title
Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo
Authors, Artists and Contributors
Author / Creator
Wanderley, Carlos WS
Schneider, Ayda H
Schiffelers, Lisa DJ
Wuerth, Jennifer D
Tödtmann, Jan MP
Maasewerd, Salie
Hawwari, Ibrahim
Duthie, Fraser
Rohland, Cornelia
Ribeiro, Lucas S
Jenster, Lea‐Marie
Rosero, Nathalia
Tesfamariam, Yonas M
Cunha, Fernando Q
Schmidt, Florian I
Franklin, Bernardo S
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c80e9b1804f64a2f89cb019c3eee47e4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c80e9b1804f64a2f89cb019c3eee47e4
Other Identifiers
ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.202115415
