SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
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Author / Creator
Romero, Octavio A. , Vilarrubi, Andrea , Alburquerque-Bejar, Juan J. , Gomez, Antonio , Andrades, Alvaro , Trastulli, Deborah , Pros, Eva , Setien, Fernando , Verdura, Sara , Farré, Lourdes , Martín-Tejera, Juan F. , Llabata, Paula , Oaknin, Ana , Saigi, Maria , Piulats, Josep M. , Matias-Guiu, Xavier , Medina, Pedro P. , Vidal, August , Villanueva, Alberto and Sanchez-Cespedes, Montse
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Despite the genetic inactivation of
SMARCA4
, a core component of the SWI/SNF-complex commonly found in cancer, there are no therapies that effectively target SMARCA4-deficient tumours. Here, we show that, unlike the cells with activated
MYC
oncogene, cells with
SMARCA4
inactivation are refractory to the histone deacetylase inhibi...
Alternative Titles
Full title
SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
Authors, Artists and Contributors
Author / Creator
Vilarrubi, Andrea
Alburquerque-Bejar, Juan J.
Gomez, Antonio
Andrades, Alvaro
Trastulli, Deborah
Pros, Eva
Setien, Fernando
Verdura, Sara
Farré, Lourdes
Martín-Tejera, Juan F.
Llabata, Paula
Oaknin, Ana
Saigi, Maria
Piulats, Josep M.
Matias-Guiu, Xavier
Medina, Pedro P.
Vidal, August
Villanueva, Alberto
Sanchez-Cespedes, Montse
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c8c005713fd44b6bbb0151fbe7d89bec
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c8c005713fd44b6bbb0151fbe7d89bec
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24618-3
