β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptos...
β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury
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Author / Creator
Zhang, Ziyue , Li, Xingbing , Guo, Jingwen , He, Bo , Wu, Lianpan , Yang, Rongpei , Li, Xingyue , Fang, Dandong , Yang, XiaoLi , Yang, Donghai , Wang, Fengxian , Tang, Ming , Han, Yu , Jose, Pedro A. , Wang, Hongyong and Zeng, Chunyu
Publisher
England: BioMed Central
Journal title
Language
English
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Publisher
England: BioMed Central
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Scope and Contents
Contents
Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain amino acids (BCAA) metabolism can protect against cardiac I/R injury, which may be related to bioactive molecules generated by BCAA metabolites. L-β-aminoisobutyric acid (L-BAIBA), a metabolite of BCAA, has multi-organ protecti...
Alternative Titles
Full title
β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c902aee8bf6a41f9a2643bb80f7808db
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c902aee8bf6a41f9a2643bb80f7808db
Other Identifiers
ISSN
1528-3658,1076-1551
E-ISSN
1528-3658
DOI
10.1186/s10020-023-00729-z
