Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease
Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease
About this item
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Author / Creator
Wang, Xin , Zhou, Xuan , Li, Gongying , Zhang, Yun , Wu, Yili and Song, Weihong
Publisher
Switzerland: Frontiers Research Foundation
Journal title
Language
English
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Publisher
Switzerland: Frontiers Research Foundation
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Scope and Contents
Contents
Alzheimer's disease (AD), the most common neurodegenerative disorder, is the leading cause of dementia. Neuritic plaque, one of the major characteristics of AD neuropathology, mainly consists of amyloid β (Aβ) protein. Aβ is derived from amyloid precursor protein (APP) by sequential cleavages of β- and γ-secretase. Although APP upregulation can pro...
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Full title
Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease
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Author / Creator
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TN_cdi_doaj_primary_oai_doaj_org_article_c90d3b7253d744279c3ed8665798ce10
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c90d3b7253d744279c3ed8665798ce10
Other Identifiers
ISSN
1662-5099
E-ISSN
1662-5099
DOI
10.3389/fnmol.2017.00294
