HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell...
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice
About this item
Full title
Author / Creator
Hoefflin, Rouven , Harlander, Sabine , Schäfer, Silvia , Metzger, Patrick , Kuo, Fengshen , Schönenberger, Désirée , Adlesic, Mojca , Peighambari, Asin , Seidel, Philipp , Chen, Chia-yi , Consenza-Contreras, Miguel , Jud, Andreas , Lahrmann, Bernd , Grabe, Niels , Heide, Danijela , Uhl, Franziska M. , Chan, Timothy A. , Duyster, Justus , Zeiser, Robert , Schell, Christoph , Heikenwalder, Mathias , Schilling, Oliver , Hakimi, A. Ari , Boerries, Melanie and Frew, Ian J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mutational inactivation of
VHL
is the earliest genetic event in the majority of clear cell renal cell carcinomas (ccRCC), leading to accumulation of the HIF-1α and HIF-2α transcription factors. While correlative studies of human ccRCC and functional studies using human ccRCC cell lines have implicated HIF-1α as an inhibitor and HIF-2α as a pr...
Alternative Titles
Full title
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice
Authors, Artists and Contributors
Author / Creator
Harlander, Sabine
Schäfer, Silvia
Metzger, Patrick
Kuo, Fengshen
Schönenberger, Désirée
Adlesic, Mojca
Peighambari, Asin
Seidel, Philipp
Chen, Chia-yi
Consenza-Contreras, Miguel
Jud, Andreas
Lahrmann, Bernd
Grabe, Niels
Heide, Danijela
Uhl, Franziska M.
Chan, Timothy A.
Duyster, Justus
Zeiser, Robert
Schell, Christoph
Heikenwalder, Mathias
Schilling, Oliver
Hakimi, A. Ari
Boerries, Melanie
Frew, Ian J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c9223cd55c18449db9d005eb65c4887e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c9223cd55c18449db9d005eb65c4887e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17873-3
