Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles
Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles
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Author / Creator
Wei, Zhaohan , Zhang, Xiaoqiong , Yong, Tuying , Bie, Nana , Zhan, Guiting , Li, Xin , Liang, Qingle , Li, Jianye , Yu, Jingjing , Huang, Gang , Yan, Yuchen , Zhang, Zelong , Zhang, Bixiang , Gan, Lu , Huang, Bo and Yang, Xiangliang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
The main challenges for programmed cell death 1(PD-1)/PD-1 ligand (PD-L1) checkpoint blockade lie in a lack of sufficient T cell infiltration, tumor immunosuppressive microenvironment, and the inadequate tumor accumulation and penetration of anti-PD-1/PD-L1 antibody. Resetting tumor-associated macrophages (TAMs) is a promising strategy to enhance T...
Alternative Titles
Full title
Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c971cb339bd0453ca49a321d5bcad548
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c971cb339bd0453ca49a321d5bcad548
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-20723-x
