Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids
Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids
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Publisher
England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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Contents
Multicellular Tumor Spheroids are frequently used to mimic the regionalization of proliferation and the hypoxic environment within avascular tumors. Here we exploit these features to study the activation of DNA damage repair pathways and their correlation to developing hypoxia.
Activation of DNA damage repair markers, proliferation, cell death,...
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Full title
Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids
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TN_cdi_doaj_primary_oai_doaj_org_article_c9831c76c4dc476b9699c410ecc5e272
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c9831c76c4dc476b9699c410ecc5e272
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ISSN
1471-2407
E-ISSN
1471-2407
DOI
10.1186/s12885-017-3319-0