Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell...
Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Only a subgroup of triple-negative breast cancer (TNBC) responds to immune checkpoint inhibitors (ICI). To better understand lack of response to ICI, we analyze 681 TNBCs for spatial immune cell contextures in relation to clinical outcomes and pathways of T cell evasion. Excluded, ignored and inflamed phenotypes can be captured by a gene classifier...
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Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_c987387dc5c94a1b93ac3cb4c523d2fd
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c987387dc5c94a1b93ac3cb4c523d2fd
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25962-0
