An activity‐based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and...
An activity‐based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and provides renewed promise for anti‐fibrotic therapeutic strategies
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United States: John Wiley & Sons, Inc
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English
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United States: John Wiley & Sons, Inc
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Dear Editor, In this study, measurement of target inhibition of lysyl oxidase-like 2 (LOXL2) in a high throughput manner from tissue lysates and blood was achieved by the tailored design of an activity-based probe (ABP), PXS-5878. Lysyl oxidases are a family of five enzymes critically responsible for the formation of cross-linked collagen and elast...
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An activity‐based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and provides renewed promise for anti‐fibrotic therapeutic strategies
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TN_cdi_doaj_primary_oai_doaj_org_article_c99b1b5618214a2193bedd33dab46b7d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c99b1b5618214a2193bedd33dab46b7d
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ISSN
2001-1326
E-ISSN
2001-1326
DOI
10.1002/ctm2.572
