iPS cell generation-associated point mutations include many C > T substitutions via different cytosi...
iPS cell generation-associated point mutations include many C > T substitutions via different cytosine modification mechanisms
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Genomic aberrations are a critical impediment for the safe medical use of iPSCs and their origin and developmental mechanisms remain unknown. Here we find through WGS analysis of human and mouse iPSC lines that genomic mutations are de novo events and that, in addition to unmodified cytosine base prone to deamination, the DNA methylation sequence C...
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iPS cell generation-associated point mutations include many C > T substitutions via different cytosine modification mechanisms
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TN_cdi_doaj_primary_oai_doaj_org_article_c9a67a6a7e1842b9b98236430276c28b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c9a67a6a7e1842b9b98236430276c28b
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-49335-5
