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Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c9b61c7dcf794ef5947cc08ad8806fa3

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Lineage plasticity, the ability of a cell to alter its identity, is an increasingly common mechanism of adaptive resistance to targeted therapy in cancer. An archetypal example is the development of neuroendocrine prostate cancer (NEPC) after treatment of prostate adenocarcinoma (PRAD) with inhibitors of androgen signaling. NEPC is an aggressive va...

Alternative Titles

Full title

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_c9b61c7dcf794ef5947cc08ad8806fa3

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c9b61c7dcf794ef5947cc08ad8806fa3

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-021-22139-7

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