METTL3-dependent m6A modification programs T follicular helper cell differentiation
METTL3-dependent m6A modification programs T follicular helper cell differentiation
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Author / Creator
Yao, Yingpeng , Yang, Ying , Guo, Wenhui , Xu, Lifan , You, Menghao , Zhang, Yi-Chang , Sun, Zhen , Cui, Xiao , Yu, Guotao , Qi, Zhihong , Liu, Jingjing , Wang, Fang , Liu, Juanjuan , Zhao, Tianyan , Ye, Lilin , Yang, Yun-Gui and Yu, Shuyang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
T follicular helper (T
FH
) cells are specialized effector CD4
+
T cells critical to humoral immunity. Whether post-transcriptional regulation has a function in T
FH
cells is unknown. Here, we show conditional deletion of METTL3 (a methyltransferase catalyzing mRNA
N
6
-methyladenosine (m
6
A) modification) in CD4
Alternative Titles
Full title
METTL3-dependent m6A modification programs T follicular helper cell differentiation
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c9bcc1a4d92f4f9192c2a0c829e54fdb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c9bcc1a4d92f4f9192c2a0c829e54fdb
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21594-6
