ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia
ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The BCL-2 inhibitor Venetoclax is a promising agent for the treatment of acute myeloid leukemia (AML). However, many patients are refractory to Venetoclax, and resistance develops quickly. ATP-binding cassette (ABC) transporters mediate chemotherapy resistance but their role in modulating the activity of targeted small-molecule inhibitors is unclea...
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ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia
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TN_cdi_doaj_primary_oai_doaj_org_article_c9c4a1f7bca449409f4ee0bf6e5c440b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c9c4a1f7bca449409f4ee0bf6e5c440b
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41229-2
