Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by...
Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment
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Full title
Author / Creator
Varone, Ersilia , Retini, Michele , Cherubini, Alessandro , Chernorudskiy, Alexander , Marrazza, Alice , Guidarelli, Andrea , Cagnotto, Alfredo , Beeg, Marten , Gobbi, Marco , Fumagalli, Stefano , Bolis, Marco , Guarrera, Luca , Barbera, Maria Chiara , Grasselli, Chiara , Bleve, Augusto , Generali, Daniele , Milani, Manuela , Mari, Michele , Salmona, Mario , Piersanti, Giovanni , Bottegoni, Giovanni , Broggini, Massimo , Janssen-Heininger, Yvonne M. W. , Cho, Jaehyung , Cantoni, Orazio and Zito, Ester
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cancer cells adapt to harsh environmental conditions by inducing the Unfolded Protein Response (UPR), of which ERO1A is a mediator. ERO1A aids protein folding by acting as a protein disulfide oxidase, and under cancer-related hypoxia conditions, it favors the folding of angiogenic VEGFA, leading tumor cells to thrive and spread. The upregulation of...
Alternative Titles
Full title
Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment
Authors, Artists and Contributors
Author / Creator
Retini, Michele
Cherubini, Alessandro
Chernorudskiy, Alexander
Marrazza, Alice
Guidarelli, Andrea
Cagnotto, Alfredo
Beeg, Marten
Gobbi, Marco
Fumagalli, Stefano
Bolis, Marco
Guarrera, Luca
Barbera, Maria Chiara
Grasselli, Chiara
Bleve, Augusto
Generali, Daniele
Milani, Manuela
Mari, Michele
Salmona, Mario
Piersanti, Giovanni
Bottegoni, Giovanni
Broggini, Massimo
Janssen-Heininger, Yvonne M. W.
Cho, Jaehyung
Cantoni, Orazio
Zito, Ester
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ca343f0894c04bfdb963681933de59a9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ca343f0894c04bfdb963681933de59a9
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-025-07426-1
