The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migrat...
The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells
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Public Library of Science (PLoS)
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English
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Public Library of Science (PLoS)
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Background The Rho-kinase ROCK II plays a major role in the activation of hepatic stellate cells (HSC), which are the key profibrotic and contractile cells contributing to the development of chronic liver disease. Inhibition of ROCK II ultimately blocks the phosphorylation of the myosin light chain (MLC) and thus inhibits stress fibre assembly and...
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The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells
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TN_cdi_doaj_primary_oai_doaj_org_article_ca41659174874eda92b1d6015a48f512
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ca41659174874eda92b1d6015a48f512
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1932-6203
