Metabolites of De Novo Purine Synthesis: Metabolic Regulators and Cytotoxic Compounds
Metabolites of De Novo Purine Synthesis: Metabolic Regulators and Cytotoxic Compounds
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Cytotoxicity of de novo purine synthesis (DNPS) metabolites is critical to the pathogenesis of three known and one putative autosomal recessive disorder affecting DNPS. These rare disorders are caused by biallelic mutations in the DNPS genes phosphoribosylformylglycineamidine synthase (PFAS), phosphoribosylaminoimidazolecarboxylase/phosphoribosylam...
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Full title
Metabolites of De Novo Purine Synthesis: Metabolic Regulators and Cytotoxic Compounds
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TN_cdi_doaj_primary_oai_doaj_org_article_ca41efae37a14af5b665d8b05d9bd17a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ca41efae37a14af5b665d8b05d9bd17a
Other Identifiers
ISSN
2218-1989
E-ISSN
2218-1989
DOI
10.3390/metabo12121210
