Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
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Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
T cell differentiation is a highly regulated, multi-step process necessary for the progressive establishment of effector functions, immunological memory, and long-term control of pathogens. In response to strong stimulation, as seen in severe or chronic infections or cancer, T cells acquire a state of hypo-responsiveness known as exhaustion, limiti...
Alternative Titles
Full title
Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
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TN_cdi_doaj_primary_oai_doaj_org_article_ca8de8bb0c084db5a04a1a6302ced457
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ca8de8bb0c084db5a04a1a6302ced457
Other Identifiers
ISSN
1756-8722
E-ISSN
1756-8722
DOI
10.1186/s13045-023-01504-7
