Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
About this item
Full title
Author / Creator
Koh, Cho Yeow , Shih, Norrapat , Yip, Christina Y. C. , Li, Aaron Wei Liang , Chen, Weiming , Amran, Fathiah S. , Leong, Esther Jia En , Iyer, Janaki Krishnamoorthy , Croft, Grace , Mazlan, Muhammad Ibrahim Bin , Chee, Yen-Lin , Yap, Eng-Soo , Monroe, Dougald M. , Hoffman, Maureane , Becker, Richard C. , de Kleijn, Dominique P. V. , Verma, Vaishali , Gupta, Amita , Chaudhary, Vijay K. , Richards, A. Mark , Kini, R. Manjunatha and Chan, Mark Y.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Despite their limitations, unfractionated heparin (UFH) and bivalirudin remain standard-of-care parenteral anticoagulants for percutaneous coronary intervention (PCI). We discovered novel direct thrombin inhibitors (DTIs) from tick salivary transcriptomes and optimised their pharmacologic activity. The most potent, ultravariegin, inhibits thrombin...
Alternative Titles
Full title
Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
Authors, Artists and Contributors
Author / Creator
Shih, Norrapat
Yip, Christina Y. C.
Li, Aaron Wei Liang
Chen, Weiming
Amran, Fathiah S.
Leong, Esther Jia En
Iyer, Janaki Krishnamoorthy
Croft, Grace
Mazlan, Muhammad Ibrahim Bin
Chee, Yen-Lin
Yap, Eng-Soo
Monroe, Dougald M.
Hoffman, Maureane
Becker, Richard C.
de Kleijn, Dominique P. V.
Verma, Vaishali
Gupta, Amita
Chaudhary, Vijay K.
Richards, A. Mark
Kini, R. Manjunatha
Chan, Mark Y.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cad6e99b695d4c66a9002c62027f15b1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cad6e99b695d4c66a9002c62027f15b1
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-27275-8
