hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia ce...
hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy
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Author / Creator
Xu, Ruidan , Yu, Shuyu , Zhu, Dan , Huang, Xinping , Xu, Yuqi , Lao, Yimin , Tian, Yonglu , Zhang, Jinfang , Tang, Zefang , Zhang, Zemin , Yi, Jing , Zhu, Hong-Hu and Zheng, Xiaofeng
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Acute myeloid leukemia (AML) is a genetically heterogeneous malignant disorder of the hematopoietic system, characterized by the accumulation of DNA-damaged immature myeloid precursors. Here, we find that hCINAP is involved in the repair of double-stranded DNA breaks (DSB) and that its expression correlates with AML prognosis. Following DSB, hCINAP...
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Full title
hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_caea99c77e2349bc964a9ae562bf4dbe
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_caea99c77e2349bc964a9ae562bf4dbe
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11795-5
